A potent, selective, brain permeable inhibitor of GSK3α and GSK3β (Kis = 6.9 and 31 nM, respectively); shows good bioavailability after oral administration in vivo, inhibiting hippocampal tau phosphorylation and reversing cognitive deficits induced by the NMDA receptor antagonist (+)-MK-801
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical inhibitor kinase protein Alzheimer's research bone-related research neuroscience glycogen synthase kinase-3α kinase-3β GSK3α GSK3β GSK-3α GSK-3β isoform phosphorylate phosphorylation inactivate inactivation synthesis disease osteogenesis AZD1080 brain permeable receptor enzyme ion channel tau cell oral administration in vivo hippocampal hippocampus cognitive deficit NMDA antagonist MK-801 MK801 human peripheral blood lymphocyte