A selective inhibitor of TGF-β type 1 receptor (TGFBR1 or ALK5; IC50 = 18 nM); inhibits the expression of collagen type I in cells (IC50 = 93 nM) and in mice when given orally at 10 mg/kg once a day; reduces typical features of fibrosis
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
1353867-76-1 biochemical inhibitor gene regulation signal transduction receptor biochemistry angiogenesis GW788388 selective inhibition transforming growth factor-β TGF-β TGFβ type 1 TGFBR1 ALK5 TGFBR-1 ALK-5 fibrosis tissue remodeling α-smooth muscle actin fibroblast in vitro signaling hypertrophy femoral growth plate rat collagen I