Recombinant Human DNA repair protein XRCC4 (XRCC4)
Description
Purity > 90% as determined by SDS-PAGE. MW: 65.3kDa. Full Length: 1-336aa. N-terminal GST-tagged. Homo sapiens (Human). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V (D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.