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Description
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. Synonyms: Monoclonal CRSP2 antibody, Anti-CRSP2 antibody, Cofactor required for Sp1 transcriptional activation subunit 2 antibody, CSRP antibody, RGR1 antibody, EXLM1 antibody, MED14 antibody, CXorf4 antibody, CRSP150 antibody, DRIP150 antibody, TRAP170 antibody, MGC104513 antibody.
Immunogen
CRSP2 antibody was raised in mouse using recombinant Human Cofactor Required For Sp1 Transcriptional Activation, Subunit 2, 150 Kda (Crsp2)