If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
Immunogen
Purified recombinant fragment of human DDR2 expressed in E. Coli.
Other Names
CD167 antigen-like family member B; CD167b; CD167b antigen; Cell migration inducing protein 20; DDR 2; DDR2; Discoidin domain containing receptor 2; Discoidin domain receptor 2; Discoidin domain receptor family member 2; discoidin domain receptor tyrosine kinase 2; Discoidin domain-containing receptor 2; discoidin domain-containing receptor tyrosine kinase 2; Hydroxyaryl protein kinase; MIG20a; Migration inducing gene 16 protein; Neurotrophic tyrosine kinase; Neurotrophic tyrosine kinase receptor related 3; NTRKR 3; NTRKR3; Receptor protein tyrosine kinase TKT; Receptor protein-tyrosine kinase TKT; Receptor related 3; receptor-related 3; TKT; TYRO 10; TYRO10; Tyrosine kinase receptor related to neurotrophic TRK; Tyrosine protein kinase TYRO 10; Tyrosine protein kinase TYRO10; Tyrosine-protein kinase TYRO10; Tyrosylprotein kinase; ddr2-