Thioredoxin Reductase 1 (TXNRD1) (AA 161-647) (Active) protein (His tag)
Description
TXNRD1 belongs to the selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. TXNRD1 decreases thioredoxins as well as other substrates, and participates in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity serves as a potential treatment for cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases Synonyms: GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR, TXNRD1, thioredoxin reductase 1, EC=1.8.1.9, Thioredoxin reductase TR1, KM-102-derived reductase-like factor, GRIM-12, kDaRF