Western blot, Immunoprecipitation, Immunohistochemistry
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Description
BRCA1 Antibody. BRCA1 is a breast cancer susceptibility gene that was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth.
Immunogen
Synthetic peptide surrounding amino acid 1852 of human BRCA1
Other Names
BRCA1, BRCA-1, breast cancer 1, breast and ovarian cancer susceptibility protein 1, RNF53, Ring Finger 53, IRIS, PSCP.