human. predicted cross reactivity with mouse, rat, bovine and Xenopus
Isotype
n/a
Format
peptide affinity purified
Size
100 μl
Concentration
n/a
Applications
Western blot, IHC, FACS.
Reviews / Ratings
If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Polyclonal Antibody to detect AKT1 in human, mouse, rat, bovine and xenopus samples. The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 and Akt 3, which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. They have a pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-? tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generat
Immunogen
This AKT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 amino acids from human AKT1.
Other Names
PKB, RAC, Protein kinase B, Protein kinase B alpha, Short PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha