An ALK1 and ALK2 inhibitor (IC50s = 1.8 and 1.1 nM, respectively) that can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling; less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA (IC50s = 34.4, 302, 321, 6.4, and 220 nM, respectively)
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
stem cells bone morphogenetic protein type I receptor BMP activin receptor-like kinase ALK SMAD complexes translocate nucleus induce transcriptional activation normal development tissue repair ALK1 ALK2 fibrodysplasia ossificans progressive cancer inhibitor intracellular signaling inhibit bone-related research biochemical biochemistry transcription factor K-02288 2-aminopyridine-based prevent BMP4-induced SMAD1/5/8 pathway in vitro dorsalization zebrafish embryo biology disease model musculoskeletal dysplasia ALK-1 ALK-2