DNA was prepared from cell line WM983C. WM983C is a metastatic human melanoma cell line. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line expresses wild type PTEN, N-RAS, c-KIT, and CDK4 genes. WM983 cells produce xenograft tumors when injected into immunocompromised mice.
Size
5 μg
Concentration
200 ng / μl
Applications
Purified Genomic DNA is suitable for a number of molecular biology applications including but not limited to preparation of genomic libraries, PCR templates, DNA sequencing, DNA fingerprinting, and mutation analysis.
Other Names
Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft