Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (Extracellular Domain)
Clone
polyclonal
Host Species
Goat
Reactive Species
mouse, rat
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor.
Immunogen
A synthetic peptide from the extracellular domain of mouse TrkB conjugated to blue carrier protein was used as the antigen. the peptide is homologous in rat.