Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (Extracellular Domain)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
rat
Isotype
n/a
Format
Protein A purified
Size
200 μg
Concentration
n/a
Applications
Western Blotting (WB)
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Description
The Trk (tropomyosin-receptor-kinase) proto-oncogene family of receptor tyrosine kinases contains four members, TrkA, Tr kb, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. Tr kb is the high-affinity to the binding brain-derived neurotrophic factor (BDNF) receptor and neurotrophin-4/5 NT-4/5). The binding of BDNF to Tr kb receptor causes many intercellular cascades to be activated such as promoting survival of sensory neurons mainly through Shc site-independent pathways.
Immunogen
TrkB antibody was raised in rabbit using the entire extracellular domain of rat TrkB receptor as the immunogen.