Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse, human
Isotype
n/a
Format
immunogen affinity purified
Size
100 μL
Concentration
n/a
Applications
Western Blotting (WB),Immunocytochemistry (ICC)
Reviews / Ratings
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Description
Cadherins are calcium-dependent cell adhesion proteins. The classic cadherin subfamily includes N-, P-, R-, B- and E-cadherins as well as about ten other members which are found in adherens junctions (AJ), E-cadherin is found at the junctions of epithelial cells. Besides mediating cell-cell adhesion through homophilic interactions, E-cadherin mediates contact inhibition of cell growth, and loss of E-cadherin is associated with tumorigenesis. E-cadherin expression is frequently down-regulated or extinguished in malignancy which strongly correlates with poor prognosis.
Immunogen
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of outside membrane of E-Cadherin.