Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (aa 650-700)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
rat, mouse, human
Isotype
n/a
Format
immunogen affinity purified
Size
40 μg
Concentration
n/a
Applications
Western Blotting (WB),Flow Cytometry (FACS)
Reviews / Ratings
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Description
E-Cadherin is a key cell adhesion molecule located at adherens junctions (AJs) and undergoes endocytosis when AJs are disrupted by the action of extracellular signals. It is a member of cadherin family that includes cadhesin repeats of approximately 100 residues in their extracellular domian. E-Cadherin plays a crucial role in the maintenance of the epithelial junctional complex and is an important molecule in maintaining epithelial integrity. The expression of E-Cadherin might be associated with the invasive potential of epithelial neoplasms. Defects in E-Cadherin are a cause of gastric cancer, also known as hereditary familial diffuse gastric cancer (HDGC).E-Cadherin Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 650-00 of human E-Cadherin (Swiss Prot: P12830).
Immunogen
KLH-coupled synthetic peptide within AA 650-700 of human E-Cadherin