A synthetic corticosteroid; a glucocorticoid receptor agonist (IC50 = 2.0 nM); increases transcriptional activity of the glucocorticoid receptor in HeLa cells (EC50 = 0.7 nM); dose-dependently inhibits VEGF secretion; decreases TNF-α-induced angiogenesis in a chick chorioallantoic membrane assay,