A c-Myc inhibitor that binds to and distorts the bHLH-ZIP domain of c-Myc (Kd = 2.8 μM), thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (IC50 = 146 μM); cytotoxic to c-Myc-overexpressing cells lines (IC50s = 15.6 and 13.5 μM for Daudi Burkitt lymphoma cells and HL60 promyelocytic leukemia cells, respectively)
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
c-Myc 10074G5 cMyc max mycmax dimerization bHLH-ZIP basic helix loop leucine zipper protein