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Description
Rabbit IgG polyclonal antibody for FAS-associated factor 1(FAF1) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. Fas-associated factor-1(FAF1) is a Fas-binding pro-apoptotic protein that is a component of the death-inducing signaling complex in Fas-mediated apoptosis. FAF1 is involved in negative regulation of NF-kappaB activation. In addition to the previously known function as a component of the Fas death-inducing signaling complex, i.e. NF-kappaB activity suppressor by cytoplasmic retention of NF-kappaB p65 via physical interaction. hFAF1 was expressed abundantly in testis, skeletal muscle, and heart as 2.8 kb mRNA. Polyclonal antibody against hFAF1 detected 74 kD protein, a deduced protein size from the ORF and 40 kD protein in some cell lines.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human FAF1(1-22aa MASNMDREMILADFQACTGIEN), identical to the related mouse and rat sequences.
Other Names
FAS-associated factor 1;hFAF1;UBX domain-containing protein 12;UBX domain-containing protein 3A;FAF1;UBXD12, UBXN3A;CGI-03;