1-147; Full length. MW: 31.99kD. Purity >90% as determined by SDS-PAGE. Involved in oxygen transport from the lung to the various peripheral tissues. LVV-horphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
Nucleotide sequence analysis of coding and noncoding regions of human beta-globin mRNA.Marotta C., Forget B., Cohen-Solal M., Weissman S.M.Prog. Nucleic Acid Res. Mol. Biol. 19:165-175(1976)