Recombinant Human Bone morphogenetic protein receptor type-1A (BMPR1A), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 56.6kDa. Cytoplasmic Domain: 177-532aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). On ligand binding, forms a receptor complex consisting of two type II and two type I transmbrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction.