Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 4
Description
2-397aa; Full Length. MW: 60kD. Purity >90% as determined by SDS-PAGE. Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MK
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.Sanchez I., Hughes R.T., Mayer B.J., Yee K., Woodgett J.R., Avruch J., Kyriakis J.M., Zon L.I.Nature 372:794-798(1994) Zon L.I.SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.Swat W., Fujikawa K., Ganiatsas S., Yang D., Xavier R.J., Harris N.L., Davidson L., Ferrini R., Davis R.J., Labow M.A., Flavell R.A., Zon L.I., Alt F.W.Immunity