Recombinant Rat Nogo-A/Nogo-66-Fc Chimera (carrier-free)
Description
Rat Nogo-A, also known as Reticulon-4, is a member of reticulon family of transmembrane proteins. Nogo-A in rat exists in four isoforms. Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. ?Isoform 4 is testis-specific. Nogo-A is one of three prototypical myelin associated neurite outgrowth inhibitory factors that may play a role in blocking the regeneration of the central nervous system in higher vertebrates. It is a negative regulator of axon-axon adhesion and neurite outgrowth. It facilitates neurite branching and regulates neurite fasciculation in the developing nervous system. It also regulates the radial migration of cortical neurons. In the adult CNS, Nogo-A is involved in the stabilization of wiring and the restriction of plasticity. The full length rat Nogo-A is 1163 amino acids long and contains 94 amino acids ‘loop’ that connects two transmembrane segments. Nogo-66 corresponds to a stretch of 66 amino acids within the 94 amino acids transmembrane connecting loop. Analysis of Nogo-A has shown that an axon-inhibiting domain of 66 amino acids is expressed at the extracellular surface and at the ER lumen of transfected cells and oligodendrocytes. Nogo-66 binds to Nogo receptor/p75 complex on axons and induces growth cone collapse.