A Hh pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 μM) without affecting Wnt signaling (IC50 ≥ 30 μM); suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression; also inhibits signaling through the oncogenic mutant SmoM2
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
1262770-72-8 inhibitors inhibits inhibitions cancers genes regulations intracellular signaling neurosciences stems cells research signals transductions HPI 1 one HPI1 hedgehogs hh pathways Sonic Wnt Gli oncogenic smoothened Smo mutants SmoM2 prevents preventions proliferations suppressors fused