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Description
Rabbit IgG polyclonal antibody for Voltage-dependent L-type calcium channel subunit alpha-1D(CACNA1D) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. Cav1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit(CACNA1D), is a human gene. It is mapped to 3p21.1. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Alpha-1D subunit can mediate DHP-sensitive, high voltage-activated, long-lasting calcium channel activity. CACNA1D can form L-type calcium channels with negative activation thresholds which is essential for normal auditory function and controling of cardiac pacemaker activity.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CaV1.3(2146-2161aa RDEEDLADEMICITTL), different from the related mouse and rat sequences by one amino acid.