Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin represents an excellent marker for the discrimination of specific subtypes of adenocarcinoma. Keratin, type I cytoskeletal 14 also known as cytokeratin-14 (CK-14) or keratin-14 (K14) is a protein that in humans is encoded by the KRT14 gene. Keratin 14 is a type I keratin. It is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Alternative Names: Cytokeratin -14 protein, Cytokeratin 14, Keratin K14 protein, Cytokeratin -14, Cytokeratin 14 protein, Cytokeratin 14