A typical antipsychotic; an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as 5-HT2A receptors (Ki = 1.8 nM); an antagonist of histamine H1, α1a-, α2b-, and α2C-adrenergic, and M3 muscarinic acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively); increases latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and stereotypic movements in the open field test in rats at 10 mg/kg; reduces cisplatin-induced emesis in dogs at 0.3, 1, and 3 mg/kg