β-Lactamase (βL), (EC 3.5.2.6), is a bacterial enzyme that hydrolyzes the β-Lactam ring, a four-carbon ring, the building block of β-Lactam antibiotics. β-Lactams inhibit transpeptidases, enzymes that participate in the biosynthesis of bacterial cell walls. Penams, Carbapenems, Cephems, Clavams, Oxacephems and Monobactams have been widely used for the treatment of bacterial infections since the discovery of penicillin, the first β-Lactam antibiotic, and its bactericidal effect more than eighty years ago. However, an alarming number of cases of β-Lactam antibiotic-resistant infections have been reported. The resistance is found in bacterial strains producing β-Lactamase, which is responsible for dimini
Size
100 assays
Concentration
n/a
Applications
Screening/studying/characterizing β-Lactamase Inhibitors for efficient treatment of antibiotic resistant bacterial infections