Purity ~90% (SDS-PAGE). Potent inhibitor of the complent membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complents of the assbling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complent binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. Source: Recombinant protein corresponding to aa26-102 from human CD59, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~11kD AA