human, mouse, rat (predicted: bovine, hamster, horse, monkey, rabbit)
Isotype
n/a
Format
immunogen affinity purified
Size
100ug (sample available)
Concentration
500ug/ml.
Applications
IHC, WB
Reviews / Ratings
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Description
Rabbit IgG polyclonal Picoband? antibody for Calcium-activated potassium channel subunit alpha-1(KCNMA1) detection. Tested with WB, IHC-P in Human;Mouse;Rat. No cross reactivity with other proteins. Calcium-activated potassium channel subunit alpha-1 also known as KCa1.1, or BK channel for short, is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by their large conductance of potassium ions (K+) through cell membranes. This gene is located on 10q22.3. BK channels are activated (opened) by changes in membrane electrical potential and/or by increases in concentration of intracellular calcium ion (Ca2+). It is essential for the regulation of several key physiological processes including smooth muscle tone and neuronal excitability. BK channels also contribute to the behavioral effects of ethanol in the worm C. elegans under high concentrations (> 100 mM, or approximately 0.50% BAC).It remains to be determined if BK channels contribute to intoxication in humans.
Immunogen
E.coli-derived human KCNMA1 recombinant protein (Position: K124-Q467). Human KCNMA1 shares 99% amino acid (aa) sequence identity with both mouse and rat KCNMA1.
Other Names
Calcium-activated potassium channel subunit alpha-1;BK channel;BKCA alpha;Calcium-activated potassium channel, subfamily M subunit alpha-1;K(VCA)alpha;KCa1.1;Maxi K channel;MaxiK;Slo-alpha;Slo1;Slowpoke homolog;Slo homolog;hSlo;KCNMA1;KCNMA, SLO;