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Description
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. Synonyms: Monoclonal Desmoglein 1 antibody, Anti Desmoglein 1 antibody, DSG1 antibody, CDHF4 antibody, DG1 antibody, Desmosomal glycoprotein 1 antibody, Cadherin family member 4 antibody, PPKS1 antibody, SPPK1 antibody.