Purity >95%. nNOS inhibitor I is a cell-permeable, selective inhibitor of nNOS (Ki = 120 nM). It displays >2,500-fold and 320-fold selectivity over eNOS and iNOS, respectively. It has been used in a rabbit model for cerebral palsy to prevent hypoxia-ischemia-induced death and to reduce the number of newborn kits exhibiting signs of cerebral palsy.
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Other Names
N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitro-guanidine, tris(2,2,2-trifluoroacetate), ncNOS, Neuronal Nitric Oxide Synthase, NOS I