D-Amino-Acid Oxidase (DAO) (AA 1-347) protein (His tag)
Description
DAAO is a peroxisomal enzyme which uses FAD (flavin adenine dinucleotide) as a cofactor and oxidizes D-AA to the corresponding AA, producing ammonia and hydrogen peroxide. DAAO substrates include an extensive array of D-AA, but it is inactive on the naturally occurring L-AA. DAAO acts on a variety of D-AA especially on those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups, however it doesn't act on acidic AA. DAAO may be involved in acid base balance in the kidney or it could act as a detoxifying agent which removes D-AA accumulated during aging. DAAO regulates the neuromodulator D-serine level in the brain. DAAO is highly active towards D-DOPA and contributes to dopamine synthesis. Creatinine inhibits the DAAO in uremia. DAAO may also have a role in the pathophysiology of schizophrenia, but not in bipolar disorder Synonyms: D-amino-acid oxidase, DAMOX, DAAO, DAO, OXDA, MGC35381