PNP, 1-289aa, Human, His tag, E Coli (Bioactivity Validated)
Description
MW: 34.2 kDa (309aa) confirmed by MALDI-TOF. Purity >90% by SDS-PAGE. PNP belongs to the PNP/MTAP phosphorylase family of proteins. This protein catalyzes the reversible phosphorolysis of ribonucleosides and 2'-deoxyribonucleosides with specificity for guanine, hypoxanthine and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in T-lymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficienc