Purity ~95% (SDS-PAGE). Nerve growth factor (NGF) receptor, also known as p75NTR, is a low affinity NGF receptor. It binds with equal affinity neurotrophins such as beta NGF, BDNF, NT-3 and NT-4. NGF receptors mediate signaling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. These receptors are also thought to play a role in neurogenerative diseases such as Alzheimers disease. The NGF receptor is a type I transmembrane glycoprotein (399aa) consisting of a signal peptide (28 aa), an extracellular domain (222aa) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22aa) and a cytoplasmic domain (155aa). Source: Nerve Growth Factor Receptor-Fc Chimera, from human DNA sequence encoding the signal peptide and extracellular domain of human NGF receptor aa1-237 was fused to the Fc region of human IgG1 aa93-330. The chimeric protein was expressed in modified human 293 cells. Molecular Weight: ~65kD-90kD