If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
alpha synuclein is a member of the synuclein family, which also includes beta and gamma synuclein. Synucleins are abundantly expressed in the brain and alpha and beta synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined.
Immunogen
Purified recombinant fragment of SNCA expressed in E. Coli.
Other Names
NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; SYN; SYUA; alpha-synuclein; synuclein; alpha; PARK1; SNCA; PD1; PARK4; synuclein, alpha (non A4 component of amyloid precursor); non A-beta component of AD amyloid; synuclein alpha-140; alpha (non A4 component of amyloid precursor); MGC110988; TLR7-like