A potent, bioavailable JAK inhibitor with preference for JAK2 (IC50 = 2 nM) over JAK1 and JAK3 (IC50s = 130 and 250 nM, respectively); effective against JAK2V617F as well as JAK2 and inhibits phosphorylation of STAT5 in vivo
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical inhibitor cancer kinase signal transduction JAK2 JAK 2 JAK1 JAK 1 JAK3 JAK 3 janus-associated kinases XL 019 JAK2 V617F phosphorylation STAT5 STAT 5