An ATP-competitive inhibitor of Hsp90 that causes degradation of client proteins, resulting in cell cycle arrest or apoptosis; orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical inhibitor cancer intracellular signaling heat shock protein apoptosis cell cycle inhibit HSP90 HSP 90 chaperone client ATP competitive XL-888 degrade arrest oral bioavailable tumor regression gastric carcinoma melanoma xenograft