An antagonist of LXRα and LXRβ (IC50s = 0.1 and 0.398 μM, respectively); inhibits LXR agonist-induced and basal expression of ABCA1 and SREBP-1c in THP-1 and HepG2 cells; binds promiscuously to a variety of nuclear receptors including RORγ, RXRα, ERα, and ERβ in a nuclear receptor specificity assay in HEK293 cells; induces the expression of fatty acid synthase and SREBP-1 in a mouse model of NAFLD