A potent inhibitor of PI3K isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively); also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively); orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models,