An inhibitor of fatty acid synthase (IC50 = 7.7 nM in an assay detecting released CoA); selective for the KR domain over the KS domain of FAS (IC50s = 29 and >10,000 nM, respectively); decreases incorporation of 13C-labeled acetate into cellular lipids in a dose-dependent manner in KATO-III, MKN-45, and SNU-1 gastric, and A549 non-small cell lung cancer cell lines; reduces cell growth of A549 cells (EC50 = 15 nM)
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
GSK-2194069 coenzyme A KATOIII MKN45 SNU1 NSCLC A-549