A peptide agonist for Y1, Y2, Y5, and Y6 receptors (EC50s = 0.7, 0.58, 1, and 0.8 nM, respectively); cleaved in vivo to PYY (3-36); released postprandially in proportion to calorie intake from intestinal enteroendocrine L cells; inhibits food intake and gastrointestinal transit in both lean and obese human subjects