Recombinant Human Ragulator complex protein LAMTOR3 (LAMTOR3)
Description
Purity > 90% as determined by SDS-PAGE. MW: 40.6kDa. Full Length: 1-124aa. N-terminal GST-tagged. Homo sapiens (Human). As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3