NELFB, Recombinant, Human, aa8-199, GST-Tag (Negative Elongation Factor B)
Description
Purity ~90% (SDS-PAGE). Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. Source: Recombinant protein corresponding to aa8-199 from human NELFB, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~48.9kD AA