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Description
Phospho-PI3-kinase p85 alpha/gamma (Tyr467/199) Antibody detects endogenous levels of PI3-kinase p85 alpha/gamma only when phosphorylated at Tyrosine 467/199. PIK3R1 is a regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.