Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington's Disease (HD). MW: 264.12. Purity ≥98% by TLC
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline