Purity > 90% as determined by SDS-PAGE. MW: 11.4kDa. Full Length of Mature Protein: 38-123aa. N-terminal 6xHis-tagged. Conus striatus (Striated cone). Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptor (GRIA1, GRIA2, GRIA3 and GRIA4). Can also open already desensitized GRIA1 receptors. Binds to a different site than does the drug cyclothiazide. The toxin acts like a straightjacket on the ligand-binding domain (LBD) gating ring of the receptor, restraining the domains via both intra- and interdimer cross-links such that agonist-induced closure of the LBD clamshells is transduced into an irislike expansion of the gating ring. Application of the toxin to hippocampal slices causes a large and rapid increase in resting AMPAR-mediated current leading to neuronal death.