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Description
anti-rat RT1.A monoclonal antibody recognizes a monomorphic determinant of rat Class I MHC antigen (RT1.A) and thus reacts with all rat strains tested including AO(RT1 ), DA (RT1 ), LEW (RT1 ) and PVG (RT1 ). However, quantitative measurements suggest that only a subfraction of the total Class I molecules are recognized (2). ABIN133217labels all peripheral lymphocytes but only a subfraction of thymocytes. It may be that the weakly labelled cells do in fact express some OX-18 antigenic determinants but there is clearly a major quantitative difference amongst thymocytes. This monoclonal used in tissue sections preferentially labels lymphoid cells in the medulla of the thymus including those cells with the marker phenotype of mature T lymphocytes. (2).
Immunogen
rat spleen membrane glycoproteins depleted of Ia-A antigens . Fusion Partner: X63 Ag8.653 . Donor: BALB/c spleen