2-201aa, Full Length of Mature Protein. MW: 22,576 Da. Purity >85% (SDS-PAGE). This protein is a transformation and shape-change sensitive actin cross-linkinggelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.