SCFFbw7 Complex, Active, Recombinant, Human (SCFFbxw7, SCFhCdc4)
Description
MW: Fbw7: ~107kD, Skp1: ~21kD, Cul1: ~93kD, Rbx1: ~12kD. Highly Purified~93% (SDS-PAGE, Coomassie blue staining). The SCF complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquit