Purity ~90% (SDS-PAGE). Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Source: Recombinant protein corresponding to aa1-81 from human NEDD8, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~35.6kD AA
Size
10ug, 50ug, 100ug
Concentration
n/a
Applications
n/a
Other Names
Neddylin Neural precursor cell expressed developmentally down-regulated protein 8