MW: ~51 kDa. Recombinant full-length human PRKAR1A Protein was expressed in Sf9 insect cells using a C-terminal His tag.Scientific Background: PRKAR1A or the cAMP-dependent protein kinase regulatory subunit type I alpha, is part of the type 1 PKA holoenzyme. PRKAR1A is found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids (1). Mutations in PRKAR1A gene cause Carney complex (CNC) and PRKAR1A can fuse to t
1. Bossis I, et al: PRKAR1A: normal and abnormal functions. Endocrinology 145: 5452-5458, 2004. 2. Casey M, et al: Mutations in the protein kinase A R1-alpha regulatory subunit cause familial cardiac myxomas and Carney complex. J. Clin. Invest. 106: R31-R38, 2000.